Thermoresponsive Polymer Grafted Porous Silicas as Smart Nanocarriers
Sushilkumar A. Jadhav A B and Dominique Scalarone AA Department of Chemistry and Nanostructured Interfaces Surfaces (NIS) Research Centre University of Torino, Via P. Giuria 7, 10125, Torino, Italy.
B Corresponding author. Email: sushil.unige@gmail.com
Australian Journal of Chemistry 71(7) 477-481 https://doi.org/10.1071/CH18229
Submitted: 20 May 2018 Accepted: 27 June 2018 Published: 17 July 2018
Abstract
Porous silica particles grafted with various stimuli-responsive polymers are investigated with great interest for their use as smart pharmaceutical nanocarriers in advanced drug delivery systems (DDS). In particular, porous silica particles grafted with thermoresponsive polymers that exhibit thermally triggered on/off gating mechanisms have shown improved performance as hybrid DDS capable of controlling the release of different drugs in various mediums which resemble complex biological environments. In addition, the tuning of the drug release profiles as per requirements has proved possible with modifications to the porous core and the grafted thermoresponsive polymers. This highlight presents a brief discussion of basic preparation techniques and some recent significant developments in the field of thermoresponsive polymer grafted porous silica particles as smart pharmaceutical nanocarriers.
References
[1] J. Florek, R. Caillard, F. Kleitz, Nanoscale 2017, 9, 15252.| Crossref | GoogleScholarGoogle Scholar |
[2] M. Vallet-Regí, F. Balas, D. Arcos, Angew. Chem. Int. Ed. 2007, 46, 7548.
| Crossref | GoogleScholarGoogle Scholar |
[3] C. Argyo, V. Weiss, C. Bräuchle, T. Bein, Chem. Mater. 2014, 26, 435.
| Crossref | GoogleScholarGoogle Scholar |
[4] D. Baeza, M. Ruiz-Molina, Vallet-Regí, Expert Opin. Drug Deliv. 2017, 14, 783.
| Crossref | GoogleScholarGoogle Scholar |
[5] S. A. Jadhav, Inorg. Chem. Front. 2014, 1, 735.
| Crossref | GoogleScholarGoogle Scholar |
[6] S. A. Jadhav, V. Brunella, G. Berlier, E. Ugazio, D. Scalarone, J. Nanomater. 2016, 2016, 1325174.
| Crossref | GoogleScholarGoogle Scholar |
[7] Y. Song, Y. Li, Q. Xu, Z. Liu, Int. J. Nanomedicine 2017, 12, 87.
| Crossref | GoogleScholarGoogle Scholar |
[8] Y. Zhao, J. L. Vivero-Escoto, I. I. Slowing, B. G. Trewyn, V. S.-Y. Lin, Expert Opin. Drug Deliv. 2010, 7, 1013.
| Crossref | GoogleScholarGoogle Scholar |
[9] Y. Chen, H. Zhang, X. Cai, J. Ji, S. He, G. Zhai, RSC Adv. 2016, 6, 92073.
| Crossref | GoogleScholarGoogle Scholar |
[10] M. Bathfield, J. Reboul, T. Cacciaguerra, P. Lacroix-Desmazes, C. Gérardin, Chem. Mater. 2016, 28, 3374.
| Crossref | GoogleScholarGoogle Scholar |
[11] D. Roy, W. L. A. Brooks, B. S. Sumerlin, Chem. Soc. Rev. 2013, 42, 7214.
| Crossref | GoogleScholarGoogle Scholar |
[12] Y. J. Kim, Y. T. Matsunaga, J. Mater. Chem. B Mater. Biol. Med. 2017, 5, 4307.
| Crossref | GoogleScholarGoogle Scholar |
[13] A. Gandhi, S. O. Paul, K. K. Sen, Asian J. Pharm. Sci. 2015, 10, 99.
| Crossref | GoogleScholarGoogle Scholar |
[14] S. A. Jadhav, V. Brunella, D. Scalarone, Part. Part. Syst. Charact. 2015, 32, 417.
| Crossref | GoogleScholarGoogle Scholar |
[15] B. Radhakrishnan, R. Ranjan, W. J. Brittain, Soft Matter 2006, 2, 386.
| Crossref | GoogleScholarGoogle Scholar |
[16] L. Wu, U. Glebe, A. Böker, Polym. Chem. 2015, 6, 5143.
| Crossref | GoogleScholarGoogle Scholar |
[17] M. Müllner, J. Cui, K. F. Noi, S. T. Gunawan, F. Caruso, Langmuir 2014, 30, 6286.
| Crossref | GoogleScholarGoogle Scholar |
[18] F. Mastrotto, P. Caliceti, V. Amendola, S. Bersani, J. P. Magnusson, M. Meneghetti, G. Mantovani, C. Alexander, S. Salmaso, Chem. Commun. 2011, 47, 9846.
| Crossref | GoogleScholarGoogle Scholar |
[19] S. Behzadi, V. Serpooshan, W. Tao, M. A. Hamaly, M. Y. Alkawareek, E. C. Dreaden, D. Brown, A. M. Alkilany, O. C. Farokhzad, M. Mahmoudi, Chem. Soc. Rev. 2017, 46, 4218.
| Crossref | GoogleScholarGoogle Scholar |
[20] M. Hei, J. Wang, K. Wang, W. Zhu, P. X. Ma, J. Mater. Chem. B Mater. Biol. Med. 2017, 5, 9497.
| Crossref | GoogleScholarGoogle Scholar |
[21] F. Yu, H. Wu, Y. Tang, Y. Xu, X. Qian, W. Zhu, Int. J. Pharm. 2018, 536, 11.
| Crossref | GoogleScholarGoogle Scholar |
[22] M. Hegazy, P. Zhou, G. Wu, L. Wang, N. Rahoui, N. Taloub, X. Huang, Y. Huang, Polym. Chem. 2017, 8, 5852.
| Crossref | GoogleScholarGoogle Scholar |
[23] Q. Wu, Y. Hou, G. Han, X. Liu, X. Tang, H. Li, X. Song, G. Zhang, Nanomedicine 2017, 12,
| Crossref | GoogleScholarGoogle Scholar |
[24] L. García-Uriostegui, H. I. Meléndez-Ortiz, G. Toriz, E. Delgado, Mater. Lett. 2017, 196, 26.
| Crossref | GoogleScholarGoogle Scholar |
[25] V. Brunella, S. A. Jadhav, I. Miletto, G. Berlier, E. Ugazio, S. Sapino, D. Scalarone, React. Funct. Polym. 2016, 98, 31.
| Crossref | GoogleScholarGoogle Scholar |
[26] S. A. Jadhav, V. Brunella, D. Scalarone, G. Berlier, Asian J. Pharm. Sci. 2017, 12, 279.
| Crossref | GoogleScholarGoogle Scholar |
[27] E. Ugazio, L. Gastaldi, V. Brunella, D. Scalarone, S. A. Jadhav, S. Oliaro-Bosso, D. Zonari, G. Berlier, I. Miletto, S. Sapino, Int. J. Pharm. 2016, 511, 446.
| Crossref | GoogleScholarGoogle Scholar |
[28] S. A. Jadhav, D. Scalarone, V. Brunella, E. Ugazio, S. Sapino, G. Berlier, Express Polym. Lett. 2017, 11, 96.
| Crossref | GoogleScholarGoogle Scholar |
[29] E. Guisasola, A. Baeza, M. Talelli, D. Arcos, M. Vallet-Regí, RSC Adv. 2016, 6, 42510.
| Crossref | GoogleScholarGoogle Scholar |
[30] E. Yu, A. Lo, L. Jiang, B. Petkus, N. Ileri Ercan, P. Stroeve, Colloids Surf. B 2017, 149, 297.
| Crossref | GoogleScholarGoogle Scholar |
[31] K. Möller, T. Bein, Chem. Mater. 2017, 29, 371.
| Crossref | GoogleScholarGoogle Scholar |
[32] J. Tu, A. L. Boyle, H. Friedrich, P. H. H. Bomans, J. Bussmann, N. A. J. M. Sommerdijk, W. Jiskoot, A. Kros, ACS Appl. Mater. Interfaces 2016, 8, 32211.
| Crossref | GoogleScholarGoogle Scholar |
[33] M. Baeza, M. Colilla, M. Vallet-Regí, Expert Opin. Drug Deliv. 2015, 12, 319.
| Crossref | GoogleScholarGoogle Scholar |
