Intermittent fasting (IF) is a dietary approach against obesity and its related comorbidities; however, investigations on the role of IF in male fertility showed contradictory results. There are complex interactions between HFD and IF on male reproductive health. IF reduces inflammation and oxidative stress by upregulating SIRT-1/NRF2 and downregulating MAPK/NLRP3. IF may have a beneficial effect on male reproductive health, emphasizing the significance of customized dietary strategies for addressing male fertility issues. Image by the authors.

This study explores the structural and functional dynamics of aromatase (CYP19A1) across cat species, including extinct and extant members. Using homology modelling and molecular dynamics simulations, we reveal key sequence differences affecting dimerisation stability and haem cofactor interactions. Compared to human aromatase, feline variants exhibit weaker dimer interfaces, particularly in solution, while membrane embedding enhances stability. These findings suggest evolutionary adaptations influencing enzymatic function and substrate processing, providing insights into steroid biosynthesis across species. Image by the authors.