Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
Table of Contents
Australian Journal of Chemistry

Australian Journal of Chemistry

Volume 65 Number 1 2012

RESEARCH FRONT: Nanomedicine

CH11370 Degradable Dextran Particles for Gene Delivery Applications

Peter R. Wich and Jean M. J. Fréchet
pp. 15-19
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A novel particulate delivery vehicle based on the degradable biopolymer dextran was used to safely transport genetic material across cell membranes. The biocompatibility and its unique tunability differentiate this new carrier system from previous particle systems, showing high potential for the treatment of several disease models in RNA interference related applications.

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Hydrophilically substituted diterpenes of the structural class of serrulatanes have attracted attention as novel antibacterial compounds. Two highly active serrulatanes convert into orange products upon separation from the plant resin extract, and this oxidative instability may be related to the mechanism of antibacterial action.

CH11292 Lipid Peptide Core Nanoparticles as Multivalent Vaccine Candidates against Streptococcus pyogenes

Mariusz Skwarczynski, Bibi Hamideh Parhiz, Fatemeh Soltani, Saranya Srinivasan, Khairul A. Kamaruzaman, I-Chun Lin and Istvan Toth
pp. 35-39
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Multivalent and monovalent vaccine candidates were synthesized with the help of an azide alkyne cycloaddition (click) reaction and their ability to self-assemble under aqueous conditions was examined. The LCP conjugates possessing two different epitopes, in contrast to monoepitopic constructs, formed potentially more immunogenic small nanoparticles (5–15 nm) presumably owing to a suitable hydrophilic-hydrophobic balance of the molecules.

CH11360 Encapsulation of Superparamagnetic Iron Oxide Nanoparticles by the Supercritical Antisolvent Process

Un Teng Lam, Roshan Yoganathan, Adam G. Carr, Raffaella Mammucari and Neil R. Foster
pp. 40-44
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Superparamagnetic iron oxide nanoparticles (SPIONs) have gained great interest in the biomedical field due to their biocompatibility and unique magnetic properties. In this work, a green method using the supercritical antisolvent system was successfully employed to produce encapsulated SPIONs of diameters less than 200 nm with an encapsulation efficiency of 70 %.

CH11364 Synthesis and X-Ray Crystal Structure of Cynandione B Analogues

Lisa P. T. Hong, Jonathan M. White and Christopher D. Donner
pp. 58-64
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The one-step conversion of benzopyranones to the heptacyclic spiroacetal core of cynandione B using methylmagnesium bromide has been achieved. The process involves a tandem Grignard addition/aldol/spiroacetal forming reaction sequence. X-ray crystal structure analysis has established the relative configuration in these novel heterocyclic products.

CH11381 Efficient Synthesis of 2,3-Dihydro-1H-Perimidine Derivatives Using HBOB as a Novel Solid Acid Catalyst

Sunanda B. Phadtare, R. Vijayraghavan, Ganapati S. Shankarling and Douglas R. MacFarlane
pp. 86-90
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We describe a simple, efficient, and green method for the synthesis of perimidine derivatives from various ketones and naphthalene-1,8-diamine using bis(oxalato)boric acid (HBOB) as a catalyst. The methodology provides an easily handled and recyclable catalyst for this type of reaction as an alternative platform to the conventional acid-catalyzed thermal processes.

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