Australian Journal of Chemistry
Volume 66 Number 6 2013
Gold nanoparticles modified with small molecules to which antibodies have been raised are shown to be able to facilitate selective binding of antibodies to these surfaces. In this case, the small molecule demonstrated is bisphenol A. This work has implications for using small-molecule-modified nanoparticles in a host of new immunoassays and immunosensors as well as highlighting their potential as substitutes for protein–hapten conjugates.
A new two-stage Grignard synthesis offers a practical preparative scale alternative to the current approach to generate tetraalkylisoindolines.
CH12570Synthesis, Chemical Characterisation, and DNA Binding Studies of Ferrocene-Incorporated Selenoureas
The interaction between cationic 1-(3-fluorobenzoyl)-3-(4-ferrocenylphenyl)selenourea (P3F) and the anionic phosphate backbone of DNA causes a variation of peak current and peak potential in cyclic voltammetry. The variation in peak current provided a DNA binding constant of 4.702 × 104 M–1 and a negative shift in the peak potential is indicative of an electrostatic interaction.
CH12548Friedel–Crafts Chemistry. Part 39. Unprecedented Facile Route to the Synthesis of Benzo[b]benzazepines via Intramolecular Friedel–Crafts Cyclialkylations
An efficient methodology for the synthesis of some novel substituted benzo[b]benzazepin-5-ones and benzo[b]benzazepines via intramolecular Friedel–Crafts cyclialkylations and cycliacylations of suitable synthesized carboxylic acids and tertiary alcohols catalyzed by Brönsted and Lewis acid catalysts is presented.
Sonogashira reaction of bromochromones and -flavones with various terminal alkynes gave the desired alkynylated products. Chromones and flavones with ethynyl functionality were prepared by removal of the trimethylsilyl protecting group.
CH13031Synthesis and Cytotoxicity Evaluation of Some Novel 1-(3-Chlorophenyl)piperazin-2-one Derivatives Bearing Imidazole Bioisosteres
1-(3-Chlorophenyl)piperazin-2-one derivatives as anticancer agents were synthesised by bioisosteric replacement of the imidazole ring of L-778123 (an anticancer agent) and evaluated against cancer cell lines. The 1-amidinourea derivative showed better cytotoxic activity.
We report an enantioselective Henry (nitroaldol) reaction catalysed by an organocatalyst using water as solvent. The enantioselective synthesis of β-nitroalcohols was achieved by using neutral chiral organocatalyst through strong hydrogen bonding which results in the formation of corresponding products in excellent yield and enantioselectivity at room temperature.
CH13090A New Series of Two-Ring-Based Side Chain Liquid Crystalline Polymers: Synthesis and Mesophase Characterization
Thermotropic side chain liquid crystalline polymers are considered as important materials because of their ability to form films, fibres, and sheets and their tendency to respond to external stimuli. A keen discussion about structure–property relationships, mesophase characteristics, and the thermal properties of a series of synthesised polymers is provided.
CH12549Trichloridothallium(III) Complexes with Bipyridine Derivatives: From Structure to Luminescence Properties.
Octahedral thallium(iii) complexes of [Tl(L)Cl3(DMSO)] (where L is a bipyridine derivative) exhibit enhanced fluorescence intensity in comparison with the related unbound bipyridine ligands, where a Tl complex with 4,4′-ditert-butyl-2,2′-bipyridine illustrates an extremely intense emission. The observation of 203,205Tl–1H spin–spin coupling in the 1H NMR spectrum confirms the stability of the titled complexes in DMSO.
CH13021Pd(II) and Pt(II) Coordination Chemistry with Hybrid Pyridine-Pyrazole Ligands: from 3D-Frameworks Structures in Molecular Complexes
In this paper we studied the reaction of hybrid pyridine-pyrazole ligands with Pd(ii) and Pt(ii). These new complexes were completely characterised. Moreover, we studied the extended structure observing that the ether, chlorine, and platinum moieties play a fundamental role in the final disposition of the supramolecular structure. All these results show how the design of an appropriate hybrid ligand can strongly influence structural control of molecular packing.
CH13057Novel Electric Responsive Columnar Liquid Crystals based on Perylene Tetra sec-alkyl Ester Derivatives
A series of perylene tetra sec-alkyl ester compounds were newly synthesised and exhibited a columnar phase at room temperature. PS8 could perpendicularly orient to the applied electric field. Well organised face-on alignment was achieved on indium tin oxide-covered glass by thermal annealing.
The competing reactions and the supramolecular interaction mechanisms between gliclazide (GLZ) and palmatine as they fight for occupancy of the cucurbituril (CB) cavity were studied using spectrofluorimetry, 1H NMR spectroscopy, and molecular modelling calculations. Based on the significant quenching of the supramolecular complex fluorescence intensity, a fluorescent probe method of high sensitivity was developed to determine GLZ in its pharmaceutical dosage forms and in human plasma with good precision and accuracy.
CH13082Multicomponent Synthesis of Novel 2-Aryl-5-((1-aryl-1H-1,2,3-triazol-4-yl)methylthio)-1,3,4-oxadiazoles using CuI as Catalyst and their Antimicrobial Evaluation
A series of novel 2-aryl-5-((1-aryl-1H-1,2,3-triazol-4-yl)methylthio)-1,3,4-oxadiazoles have been synthesised using a multicomponent approach utilising the catalytic activity of CuI. These novel products are further evaluated for antimicrobial activity and show moderate results.