Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
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Continuous Flow Synthesis of Organic Electronic Materials – Case Studies in Methodology Translation and Scale-up

Helga Seyler A , Stefan Haid B , Tae-Hyuk Kwon A C , David J. Jones A , Peter Bäuerle B , Andrew B. Holmes A and Wallace W. H. Wong A D

A School of Chemistry, Bio21 Institute, University of Melbourne, Vic. 3010, Australia.

B Institute of Organic Chemistry II and Advanced Materials, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.

C Current address: Interdisciplinary School of Green Energy, Ulsan National Institute of Science and Technology, UNIST-gil 50, Eonyang-eup, Ulju-gun, Ulsan 689-798, Republic of Korea.

D Corresponding author. Email: wwhwong@unimelb.edu.au

Australian Journal of Chemistry 66(2) 151-156 http://dx.doi.org/10.1071/CH12406
Submitted: 1 September 2012  Accepted: 3 October 2012   Published: 19 November 2012

Abstract

The continuous flow synthesis of functional thiophene derivatives was examined. Methodology for the lithiation of thiophene building blocks was developed using a commercial bench-top flow reactor. In addition, the advantages of flow processing were demonstrated in the synthesis of a high performance organic dye in gram scale.

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