Two New Scalarane Sesterterpenes: Isoscalarafuran-A and -B, Epimeric Alcohols From a Southern Australian Marine Sponge, Spongia hispida

Abstract

A specimen of the marine sponge Spongia hispida ( Lamarck , 1814), collected in the Great Australian Bight, has yielded the known marine sesterterpene hyrtiosal (1), together with two new scalarane sesterterpenes, isoscalarafuran-A (2) and isoscalarafuran -B (3). The structures for these two new metabolites were secured by detailed spectroscopic analysis, comparison with model compounds, and molecular modelling.