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REVIEW
Contents Vol 66(3)

Multi-Bond Forming Processes in Efficient Synthesis*

Nicholas J. Green A and Michael S. Sherburn A B
+ Author Affiliations
- Author Affiliations

A Australian Research Council Centre of Excellence for Free Radical Chemistry and Biotechnology, Research School of Chemistry, Australian National University, Canberra, ACT 0200, Australia.

B Corresponding author. Email: sherburn@rsc.anu.edu.au




Nicholas Green is currently a Ph.D. student in the Sherburn research group at the Research School of Chemistry, the Australian National University (ANU). He studied a Ph.B. (Science) at the ANU and received an Honours degree with the University Medal in 2011, taking up doctoral studies as a Rodney Rickards scholar soon after. His research interests include the use of highly unsaturated molecules in synthesis and the catalytic, enantioselective Diels–Alder reaction.


Professor Michael Sherburn studied chemistry at the University of Nottingham, UK, and received his Ph.D. in 1991 with John A. Murphy. He then moved to Australia and worked as a post-doctoral fellow in the Research School of Chemistry, the Australian National University (ANU) with Lewis N. Mander. He held academic positions at Massey University in New Zealand and the University of Sydney before being appointed at the Research School of Chemistry, ANU in 2002. His awards include the Le Fèvre Memorial Prize of the Australian Academy of Science (2006) and the A. J. Birch Medal of the RACI (2008).

Australian Journal of Chemistry 66(3) 267-283 https://doi.org/10.1071/CH13003
Submitted: 2 January 2013  Accepted: 1 February 2013   Published: 18 March 2013

Abstract

An increasing number of synthetic organic chemists are embracing the philosophy of efficiency. Herein we highlight multi-bond forming processes, which form two or more new covalent bonds in a single synthetic operation. Such processes, which have the ability to rapidly increase structural complexity, are preeminent in contemporary synthetic organic chemistry. In this short review we classify, analyse, and contrast contemporary multi-bond forming processes, frame these cutting edge contributions within a historical context, and speculate on likely future developments in the area.


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