CH25035A red-emission fluorescent probe for monitoring polarity changes during ER stress induced by DTT
Xue Zhang, Feiyang Ding, Jiale Li, Aobo Sun, Sichen Zhang, Jie Wang, Lei Hu and Hui Wang 
A series of red-emission compounds (ER-A, ER-B, ER-C) have been constructed using methyl sulfonamide as the ER-targeting moiety. These compounds can effectively detect environmental polarity changes within a defined range. ER-A exhibits high ER localisation accuracy (colocalisation coefficient = 0.9) and detects polarity changes under ER stress. This work provides a novel tool for monitoring ER polarity and studying related diseases. (Image credit: Xue Zhang.)
