CH25003Friedel–Crafts chemistry. Part 64. Facile syntheses of fused azepinoindoles by Jourdan–Ullmann and Friedel–Crafts approaches
Indole fused N-heterocycles form the structural core of a large number of natural products and pharmaceuticals. These properties make them exciting targets for synthetic chemists, with a wide range of synthetic methodologies reported. However, these often have a number of drawbacks, including cost, scalability and low yields. Herein, we explore an efficient construction of benzo-, pyrido-, thieno-, naphtho-fused azepinoindolones and indolo-azepinoquinolinones from readily available starting materials through Lewis and Brønsted acid mediated Friedel–Crafts reactions. (Image credit: Hassan A. K. Abd El-Aal.)